Qualitative interview methods

Addiction

  • Interviews and Rasch analysis in opioid addiction

Allergic conditions

  • Development of a COA strategy to measure treatment side effects for peanut allergy treatments

Autoimmune diseases

  • Assessing utility for flares in systemic lupus erythematosus in the UK, France, Spain, Australia and Canada, including training and managing local interviewing agencies and providing support to local teams
  • Key opinion leader contracting and additional interviews for assessing utility in various severities of flares in systemic lupus erythematosus

Cardiovascular disease

  • PRO claims for pulmonary arterial hypertension – endpoint review, regulatory support for the FDA and EMEA and qualitative patient interviews
  • Key opinion leader interviews on neurogenic orthostatic hypotension

Central nervous system/neurology

  • Development of an online therapy tool for depression along with a landscape analysis, structured and grey literature review, local language literature review, gap analysis, local language payer interviews and clinician interviews
  • Interview study to understand the experience of walking pain among patients with diabetic peripheral neuropathy
  • Interviews on the development of a composite trial endpoint for Dravet’s syndrome
  • Development of a conceptual framework and endpoint model in insomnia, plus qualitative patient interviews to confirm the validity of the conceptual framework and the psychometric validation of the final conceptual framework
  • Qualitative interviews in chronic migraine headaches
  • Regulatory consulting to support development of a structured diagnostic interview and severity scale in paediatric RLS, along with development of two manuscripts to document the development and validation process
  • Development and validation of a diagnostic interview and severity scale for paediatric RLS
  • Endpoint review and strategic recommendations on the application of the Zarit Burden Interview (ZBI) to assess caregiver burden in schizophrenia

Dermatology

  • Concept elicitation interviews in acne vulgaris to reach saturation
  • Analysis, reporting and patient interviews PRO in acne vulgaris
  • Patient interviews for the development of alopecia-related PRO measures
  • Qualitative interviews to evaluate the psychological impact of the brow satisfaction questionnaire and to validate in a post-chemotherapy population
  • Qualitative interviews to support the concept of psychological impact on the facial line outcomes questionnaire
  • Qualitative analysis of patient interviews to identify how subjects describe the severity of crow’s feet
  • Interviews with patient focus groups in psoriasis
  • Patient interviews and reporting on a photoguide in rosacea
  • Consulting on patient qualitative insight blogs with follow-up interviews to explore wound scar healing
  • Development of PRO and ClinRO instruments for alopecia totalis and alopecia universalis

Endocrinology and metabolic diseases

  • Patient interviews in type 2 diabetes for development of a new PRO measure
  • Interviews with patients with diabetes-induced edema in the USA
  • Interview study to understand the experience of walking pain among patients with diabetic peripheral neuropathy
  • Outcomes interviews in phenylketonuria, resource use and impact on patients
  • Development and validation of a patient-reported outcome measure for non-alcoholic steatohepatitis

Gastrointestinal diseases

  • In-depth interviews, instrument development and cognitive debriefing related to measurement of opioid-induced constipation
  • Patient interviews to assess content validity of an instrument for use in opioid-induced constipation
  • Qualitative interviews to develop a symptom measure in adult patients with eosinophilic esophagitis
  • Sub-group analysis of gastroparesis patients interviewed in exploratory phase, Rasch analysis and PCA on a 5 item scale
  • Patient interviews and qualitative work on IBS
  • Independent analysis, evidence saturation and report on 30 interviews in IBS-C
  • Long term safety study and participation interviews in chronic constipation and IBS-C
  • Manuscript based on the findings of the exit interview study of patients taking a treatment for IBS-C within a long term safety study
  • Interviews with clinicians to understand diagnoses of paediatric IBS-C and CC
  • Language validation interview for an ascites impact questionnaire
  • Support with interviews in paediatric vomiting

Genetic disorders

  • Qualitative interviews and development of a COA strategy for Down’s syndrome in adults and children
  • Patient interviews to support a PRO submission package in hereditary angioedema
  • Patient interviews for the face and content validation of the Patient Global Impression in hereditary angioedema
  • Endpoint review and caregiver interviews in Sanfilippo syndrome
  • Concept elicitation interviews in Barth Syndrome patients
  • Qualitative concept elicitation and case studies documenting the disease progression of Barth Syndrome

Haematology

  • Exit interviews to assess the impact of infusion frequency in haemophilia A
  • IRB submission for haemophilia patient interviews
  • Clinician and patient interviews for a PRO in iron overload
  • Caregiver interviews to support content validity of an ObsRO in a paediatric population with severe aplastic anaemia (SAA) and chronic immune thrombocytopenic purpura (CITP)
  • Qualitative interviews with patients with myelodysplastic syndrome

Immunology

  • Cognitive Debriefing of the Eosinophilic Esophagitis Activity Index (EEsAI)

Infectious diseases

  • Concept elicitation and cognitive debriefing interviews with hepatitis C patients in multiple countries
  • Consulting on the development of a PRO strategy for international HIV trials with interviews in the US and Puerto Rico

Men’s health

  • Patient interviews to support the development of an FDA dossier on an erection hardness score questionnaire

Musculoskeletal diseases

  • Patient interviews on rheumatoid arthritis
  • Pilot testing interviews on fibromyalgia fatigue
  • Patient interviews and manuscript on the development of a PRO strategy to support labelling claims in gout
  • Focus group interviews with patients with chronic low back pain
  • Qualitative exit interviews to assess the patient experience of treatment and clinical trial participation among patients with chronic low back pain and osteoarthritis

Nephrology

  • Qualitative interviews, conceptual model and strategic consulting on autosomal dominant polycystic kidney disease (ADPKD)

Oncology

  • Patient interviews to investigate side effects of breast cancer treatment
  • Qualitative interviews to assess equivalence of paper and electronically administered questionnaires in head and neck cancer
  • Qualitative interviews to understand the impact of non-small cell lung cancer (NSCLC) on quality of life
  • Qualitative interviews to understand the impact of NSCLC on caregivers and family members
  • Exploratory qualitative interviews in NSCLC patients to assess progression-free survival
  • Patient interviews in lung cancer
  • Strategic PRO endpoint support, gap analysis and patient interviews in a biological therapy treatment for non-Hodgkin’s lymphoma
  • Pilot patient interviews in melanoma
  • Pre-screen interviews for the relative resource utilization of intravenous and subcutaneous drug administration in metastatic bone disease
  • Patient interviews in multiple myeloma and development of a poster on the results
  • Burden of relapse in multiple myeloma: communicating the findings from patient and physician interviews in the EU5
  • Expert interviews and amendment project to heath economic model for a treatment for breakthrough cancer pain

Ophthalmology

  • Patient interviews on glaucoma treatment characteristics and outcomes: unmet patient needs & value drivers
  • Brief literature reviews and patient interviews to inform development of PRO strategies in retinitis pigmentosa – stages 1, 2 and 3
  • Exploratory interviews to confirm the benefits of an experimental treatment in retinitis pigmentosis
  • Analysis and reporting on completed interviews about eyelid swelling

Respiratory diseases

  • Exit interviews and evaluation of the psychometric properties of the Asthma Daily Symptom Diary (ADSD) in severe asthma
  • Exit interviews to provide additional evidence of content validity for a quantitative study in asthma
  • Clinical trial exit interviews to characterise patients’ experience and treatment benefit in patients with activated phosphoinositide 3-kinase delta syndrome (APDS)
  • Content validation of a COA strategy for respiratory syncytial virus (RSV) and influenza in the elderly or in those with respiratory compromise
  • Exit interviews with caregivers and clinicians in a prospective study to assess the Paediatric Respiratory Syncytial Virus (RSV) Electronic Severity and Outcome Rating System (PRESORS)
  • Exit interviews on a connected inhaler system for asthma

Women’s health

  • Patient interviews and analysis/report on the Female Sexual Desire Profile (FSDP) and Female Sexual Encounter Profile (FSEP)
  • Qualitative research to assess the content validity of the dysmenorrhea daily diary (DysDD) in patients with endometriosis